abstract：:A major drawback in the operation of mechanical heart valve prostheses is thrombus formation in the near valve region. Detailed flow analysis in this region during the valve closure phase is of interest in understanding the relationship between shear stress and platelet activation. A fixed-grid Cartesian mesh flow sol...

journal_title：Annals of biomedical engineering

authors： Krishnan S,Udaykumar HS,Marshall JS,Chandran KB

更新日期：2006-10-01 00:00:00

abstract：:This paper describes the development and use of a direct compression stimulator for culturing explants from the meniscus of the knee and articular cartilage. Following design and fabrication of the instrument along with its data acquisition system, the function of the machine was verified by both mechanical means and ...

journal_title：Annals of biomedical engineering

authors： Aufderheide AC,Athanasiou KA

更新日期：2006-09-01 00:00:00

abstract：:In this study various blood rheological assumptions are numerically investigated for the hemodynamic properties of intra-stent flow. Non-newtonian blood properties have never been implemented in blood coronary stented flow investigation, although its effects appear essential for a correct estimation and distribution o...

journal_title：Annals of biomedical engineering

authors： Benard N,Perrault R,Coisne D

更新日期：2006-08-01 00:00:00

abstract：:Collagen is known to be a viscoelastic material and therefore is an important source of time dependent behavior in soft tissue. Though there are material models for soft tissue that rely on properties and structure of constituent collagen fibers, such models generally utilize only the elastic properties of collagen, a...

journal_title：Annals of biomedical engineering

authors： Bischoff JE

更新日期：2006-07-01 00:00:00

abstract：:A study that customizes the feature generator parameters of an asynchronous Brain Interface (BI) is discussed. The goal is to detect the presence of a certain pattern, in the ongoing EEG, associated with a specific movement and to improve the system's performance. Results of this study show that customization mostly b...

journal_title：Annals of biomedical engineering

authors： Bashashati A,Fatourechi M,Ward RK,Birch GE

更新日期：2006-06-01 00:00:00

abstract：:Polymeric heart valves have the potential to reduce thrombogenic complications associated with current mechanical valves and overcome fatigue-related problems experienced by bioprosthetic valves. In this paper we characterize the in vitro velocity and Reynolds Shear Stress (RSS) fields inside and downstream of three d...

journal_title：Annals of biomedical engineering

authors： Leo HL,Dasi LP,Carberry J,Simon HA,Yoganathan AP

更新日期：2006-06-01 00:00:00

abstract：:Continued progress in the field of Brain Interface (BI) research has encouraged the rapid expansion of the BI community over the last two decades. As the number of BI researchers and organizations steadily increases, newer and more advanced technologies are constantly produced, evaluated, and reported. Though the BI c...

journal_title：Annals of biomedical engineering

authors： Jackson MM,Mason SG,Birch GE

更新日期：2006-05-01 00:00:00

abstract：:Rapid technological advances have prompted the development of a wide range of telemonitoring systems to enable the prevention, early diagnosis and management, of chronic conditions. Remote monitoring can reduce the amount of recurring admissions to hospital, facilitate more efficient clinical visits with objective res...

journal_title：Annals of biomedical engineering

authors： Ní Scanaill C,Carew S,Barralon P,Noury N,Lyons D,Lyons GM

更新日期：2006-04-01 00:00:00

abstract：:To study pulsatile pressure-flow rate relationships in the intact pulmonary vascular network of mice, we developed a protocol for measuring pulmonary vascular resistance and impedance in isolated, ventilated, and perfused mouse lungs. We used pulmonary emboli to validate the effect of vascular obstruction on resistanc...

journal_title：Annals of biomedical engineering

authors： Tuchscherer HA,Webster EB,Chesler NC

更新日期：2006-04-01 00:00:00

abstract：:Interstitial fluid flow, critical for macromolecular transport, was recently shown to drive fibroblast differentiation and perpendicular cell and matrix alignment in 3D collagen cultures. Here we explore the mechanisms underlying this flow-induced cell and collagen alignment. Cell and matrix alignment was assessed fro...

journal_title：Annals of biomedical engineering

authors： Ng CP,Swartz MA

更新日期：2006-03-01 00:00:00

abstract：:Cells function based on a complex set of interactions that control pathways resulting in ultimate cell fates including proliferation, differentiation, and apoptosis. The inter-workings of this immensely dense network of intracellular molecules are influenced by more than random protein and nucleic acid distribution wh...

journal_title：Annals of biomedical engineering

authors： LeDuc PP,Bellin RR

更新日期：2006-01-01 00:00:00

abstract：:In this paper, we present the application of a semi-global inverse method for determining material parameters of biological tissues. The approach is based on the successive response surface method, and is illustrated by fitting constitutive parameters to two nonlinear anisotropic constitutive equations, one for aortic...

journal_title：Annals of biomedical engineering

authors： Einstein DR,Freed AD,Stander N,Fata B,Vesely I

更新日期：2005-12-01 00:00:00

abstract：:One of the major functions of the cardiovascular system is to deliver blood to the microcirculation where exchange of mass and energy can take place. In the present article, we will provide an overview of the state-of-the-art computational methods for modeling of red blood cell (RBC) rheology and dynamics in the micro...

journal_title：Annals of biomedical engineering

authors： Cristini V,Kassab GS

更新日期：2005-12-01 00:00:00

abstract：:The development of brain interface (BI) technology continues to attract researchers with a wide range of backgrounds and expertise. Though the BI community is committed to accurate and objective evaluation of methods, systems, and technology, the very diversity of the methods and terminology used in the field hinders ...

journal_title：Annals of biomedical engineering

authors： Mason SG,Jackson MM,Birch GE

更新日期：2005-11-01 00:00:00

abstract：:The temporal and spatial distribution of coronary blood flow, pressure, and volume are determined by the branching pattern and three-dimensional (3-D) geometry of the coronary vasculature, and by the mechanics of heart wall and vascular tone. Consequently, a realistic simulation of coronary blood flow requires, as a f...

journal_title：Annals of biomedical engineering

authors： Kaimovitz B,Lanir Y,Kassab GS

更新日期：2005-11-01 00:00:00

abstract：:The finite element method is employed to simulate two-dimensional (axisymmetric) drug diffusion from a finite drug reservoir into the skin. The numerical formulation is based on a general mathematical model for multicomponent nonlinear diffusion that takes into account the coupling effects between the different compon...

journal_title：Annals of biomedical engineering

authors： Rim JE,Pinsky PM,van Osdol WW

更新日期：2005-10-01 00:00:00

abstract：:The pericellular matrix (PCM) is a region of tissue that surrounds chondrocytes in articular cartilage and together with the enclosed cells is termed the chondron. Previous studies suggest that the mechanical properties of the PCM, relative to those of the chondrocyte and the extracellular matrix (ECM), may significan...

journal_title：Annals of biomedical engineering

authors： Guilak F,Alexopoulos LG,Haider MA,Ting-Beall HP,Setton LA

更新日期：2005-10-01 00:00:00

abstract：:Calcium phosphate ceramics have been widely used for filling bone defects to aid in the regeneration of new bone tissue. Addition of osteogenic cells to porous ceramic scaffolds may accelerate the bone repair process. This study demonstrates the feasibility of culturing marrow stromal cells (MSCs) on porous biphasic c...

journal_title：Annals of biomedical engineering

authors： Holtorf HL,Sheffield TL,Ambrose CG,Jansen JA,Mikos AG

更新日期：2005-09-01 00:00:00

abstract：:Crowding can substantially affect the transition of a protein between its native (N) and unfolded (U) states via volume exclusion effects. Also, it influences considerably the aggregation (A) of unfolded proteins. To examine the details, we developed an approach for computing the kinetic rates of the process N <--> U ...

journal_title：Annals of biomedical engineering

authors： Despa F,Orgill DP,Lee RC

更新日期：2005-08-01 00:00:00

abstract：:A rigorous analysis of blood flow must be based on the branching pattern and vascular geometry of the full vascular circuit of interest. It is experimentally difficult to reconstruct the entire vascular circuit of any organ because of the enormity of the vessels. The objective of the present study was to develop a nov...

journal_title：Annals of biomedical engineering

authors： Mittal N,Zhou Y,Ung S,Linares C,Molloi S,Kassab GS

更新日期：2005-08-01 00:00:00

abstract：:Modern models of cardiac membranes are often highly complex and computationally expensive, particularly when used in long simulations of spatially extended models of cardiac tissue. Therefore, there is a need for simpler membrane models that preserve the features of the complex models deemed important. This communicat...

journal_title：Annals of biomedical engineering

authors： Oliver RA,Krassowska W

更新日期：2005-07-01 00:00:00

abstract：:Traumatic falls are a prevalent and costly threat to elderly adults. Accurate risk assessment is necessary for reducing incidence of falls. The objective of this study was to test the feasibility of a balance impairment detection model using tasks of sample categorization and falls risk estimation. Model design includ...

journal_title：Annals of biomedical engineering

authors： Hahn ME,Chou LS

更新日期：2005-06-01 00:00:00

abstract：:This study presents a generic numerical model to simulate the coupled solute and solvent transport in tissue sections during addition and removal of chemical additives or cryoprotective agents (CPA; dimethylsulfoxide or DMSO). Osmotic responses of various tissue cells within the artificial tissue are predicted by the ...

journal_title：Annals of biomedical engineering

authors： He Y,Devireddy RV

更新日期：2005-05-01 00:00:00

abstract：:This paper describes a finite volume method for modeling electrical activation in a sample of cardiac tissue using the bidomain equations. Microstructural features to the level of cleavage planes between sheets of myocardial fibers in the tissue are explicitly represented. The key features of this implementation compa...

journal_title：Annals of biomedical engineering

authors： Trew M,Le Grice I,Smaill B,Pullan A

更新日期：2005-05-01 00:00:00

abstract：:The nose is the front line defender of the respiratory system. Unsteady simulations in three-dimensional models have been developed to study transport patterns in the human nose and its overall air-conditioning capacity. The results suggested that the healthy nose can efficiently provide about 90% of the heat and the ...

journal_title：Annals of biomedical engineering

authors： Naftali S,Rosenfeld M,Wolf M,Elad D

更新日期：2005-04-01 00:00:00

abstract：:Arterial restenosis following stent deployment may be influenced by the local flow environment within and around the stent. We have used computational fluid dynamics to investigate the flow field in the vicinity of model stents positioned within straight and curved vessels. Our simulations have revealed the presence o...

journal_title：Annals of biomedical engineering

authors： Seo T,Schachter LG,Barakat AI

更新日期：2005-04-01 00:00:00

abstract：:There is a high incidence of low back pain (LBP) associated with occupations requiring sustained and/or repetitive lumbar flexion (SLF and RLF, respectively), which cause creep of the viscoelastic tissues. The purpose of this study was to determine the effect of creep on lumbar biomechanics and facet joint capsule (FJ...

journal_title：Annals of biomedical engineering

authors： Little JS,Khalsa PS

更新日期：2005-03-01 00:00:00

abstract：:Coronary artery bypass graft (CABG) failure has been linked to graft hemodynamics, in particular wall shear stress. This study characterizes the morphology, geometry and wall shear stress patterns in human CABGs. The intimal thickness (IT) in 49 human saphenous vein CABGs was measured by digital light microscopy. The ...

journal_title：Annals of biomedical engineering

authors： Leask RL,Butany J,Johnston KW,Ethier CR,Ojha M

更新日期：2005-03-01 00:00:00

abstract：:A theoretical model is presented for describing the motion of a deformable cell encapsulating a Newtonian fluid and enclosed by an elastic membrane in tube flow. In the mathematical formulation, the interior and exterior hydrodynamics are coupled with the membrane mechanics by means of surface equilibrium equations, a...

journal_title：Annals of biomedical engineering

authors： Pozrikidis C

更新日期：2005-02-01 00:00:00

abstract：:Bone loss during long-term space flight is potentially a significant problem. Bone mineral density measurements show that bone is lost at a rate of about 1% per month from the lumbar spine, and 1.5% per month from the hip. Bone density changes are not uniform throughout the skeleton, and there is accumulating evidence...

journal_title：Annals of biomedical engineering

authors： McCarthy ID

更新日期：2005-01-01 00:00:00

abstract：:Diluted serum provides a model of interstitial fluid that can be used to study the response of smooth muscle cells (SMCs) to interstitial flow. The effect of serum and some of its components on SMC contraction (area reduction) and intracellular calcium ([Ca2+]i) response were characterized in rat aortic SMC in vitro. ...

journal_title：Annals of biomedical engineering

authors： Ainslie K,Shi ZD,Garanich JS,Tarbell JM

更新日期：2004-12-01 00:00:00

abstract：:Finite element analysis is a powerful tool for investigating the biomechanics of atherosclerosis and has thereby provided an improved understanding of acute myocardial infarction. Structural analysis of arterial walls is traditionally performed using geometry contours derived from histology. In this paper we demonstra...

journal_title：Annals of biomedical engineering

authors： Chau AH,Chan RC,Shishkov M,MacNeill B,Iftimia N,Tearney GJ,Kamm RD,Bouma BE,Kaazempur-Mofrad MR

更新日期：2004-11-01 00:00:00

abstract：:Rod photoreceptors express a unique type of noninactivating potassium channels, Kx channels, which play an important role in setting the dark potential and participate in shaping the light response. Biophysical studies of Kx channels are limited. For example, the effects of a conventional blocker of potassium channels...

journal_title：Annals of biomedical engineering

authors： Liu XD,Kourennyi DE

更新日期：2004-10-01 00:00:00

abstract：:Experimental and diagnostic procedures like distension of a balloon catheter, bougie, and esophagogastroduodenoscopy can induce shear deformation in the esophageal wall. However, the shear modulus of the esophagus is yet unknown. The aim of this study was to determine the esophageal shear modulus and its dependence on...

journal_title：Annals of biomedical engineering

authors： Yang J,Liao D,Zhao J,Gregersen H

更新日期：2004-09-01 00:00:00

abstract：:An algorithm to track a rat swimming in a Morris Water Maze has been developed. The system is automatically configured to any pool and relative suitable light conditions. It tracks the rat's position and head pose 10 times per second. The output data is displayed in a bitmap and also in a text file. The system was tes...

journal_title：Annals of biomedical engineering

authors： Hval ES,Barrett SF,Wilcox M,Bailey TA

更新日期：2004-08-01 00:00:00

abstract：:Biologically active heart valves (tissue engineered and recellularized tissue-derived heart valves) have the potential to offer enhanced function when compared to current replacement value therapies since they can possibly remodel, and grow to meet the needs of the patient, and not require chronic medication. However,...

journal_title：Annals of biomedical engineering

authors： Hildebrand DK,Wu ZJ,Mayer JE Jr,Sacks MS

更新日期：2004-08-01 00:00:00

abstract：:The identification of the insulin minimal model (MM) for the estimation of insulin secretion rate (ISR) and physiological indexes (e.g. beta-cell sensitivity) requires the knowledge of C-peptide (CP) kinetics. The four parameters of the two-compartment model of CP kinetics in a given individual can be derived either f...

journal_title：Annals of biomedical engineering

authors： Magni P,Sparacino G,Bellazzi R,Toffolo GM,Cobelli C

更新日期：2004-07-01 00:00:00

abstract：:Proper replacement or repair of damaged tendons or ligaments requires functionally engineered tissue that mimics their native mechanical properties. While tendon structure-function relationships are generally assumed, there exists little quantitative evidence of the roles of distinct tendon components in tendon functi...

journal_title：Annals of biomedical engineering

authors： Robinson PS,Lin TW,Jawad AF,Iozzo RV,Soslowsky LJ

更新日期：2004-07-01 00:00:00

abstract：:In this paper, an intelligent proportional-integral-derivative (PID) control method is introduced to the robotic testing system for the biomechanical study of human musculoskeletal joints. For the testing system, the robot is a highly nonlinear and heavily coupled complicated system, and the human spinal specimen also...

journal_title：Annals of biomedical engineering

authors： Tian L

更新日期：2004-06-01 00:00:00

abstract：:"Smart" drug delivery systems should be selective and effective to ensure drug administration at the right time, at the right dosage, and anywhere in the body. Among the several administration routes and delivery systems that have been proposed, one of the most effective and promising is based on microfabricated parti...

journal_title：Annals of biomedical engineering

authors： Decuzzi P,Lee S,Decuzzi M,Ferrari M

更新日期：2004-06-01 00:00:00